49ers at Jaguars

49ers 4–2 straight up · 5–1 against the spread · overs 2–4 · 6 meetings

• SF 30–10

  Nov 21, 2021 · W11 · @ JAX
  −6.5 ✓

  Under 45
• SF 44–33

  Dec 24, 2017 · W16 · @ SF
  +4 ✓

  Over 43
• SF 42–10

  Oct 27, 2013 · W8 · Neutral
  −16 ✓

  Over 40
• SF 20–3

  Nov 29, 2009 · W12 · @ SF
  −3 ✓

  Under 42.5
• SF 9–10

  Dec 18, 2005 · W15 · @ JAX
  +14.5 ✓

  Under 39.5
• SF 3–41

  Sep 12, 1999 · W1 · @ JAX
  +5.5 ✗

  Under 49