49ers at Bills

49ers 3–3 straight up · 3–3 against the spread · overs 4–2 · 6 meetings

• SF 24–34

  Dec 7, 2020 · W13 · Neutral
  −1.5 ✗

  Over 48
• SF 16–45

  Oct 16, 2016 · W6 · @ BUF
  +7.5 ✗

  Over 44
• SF 45–3

  Oct 7, 2012 · W5 · @ SF
  −10 ✓

  Over 45.5
• SF 10–3

  Nov 30, 2008 · W13 · @ BUF
  +6.5 ✓

  Under 43
• SF 7–41

  Dec 26, 2004 · W16 · @ SF
  +10 ✗

  Over 41.5
• SF 35–0

  Dec 2, 2001 · W12 · @ SF
  −8.5 ✓

  Under 44.5