49ers at Colts

49ers 1–5 straight up · 2–4 against the spread · overs 3–3 · 6 meetings

• SF 18–30

  Oct 24, 2021 · W7 · @ SF
  −3.5 ✗

  Over 41.5
• SF 23–26

  Oct 8, 2017 · W5 · @ IND
  −1 ✗

  Over 43.5
• SF 7–27

  Sep 22, 2013 · W3 · @ SF
  −10.5 ✗

  Under 45.5
• SF 14–18

  Nov 1, 2009 · W8 · @ IND
  +13 ✓

  Under 45
• SF 3–28

  Oct 9, 2005 · W5 · @ SF
  +14 ✗

  Under 47
• SF 40–21

  Nov 25, 2001 · W11 · @ IND
  +2.5 ✓

  Over 52.5