49ers at Rams

49ers 30–24–1 straight up · 30–23–2 against the spread · overs 27–28 · 55 meetings

• SF 26–42

  Nov 9, 2025 · W10 · @ SF
  +5.5 ✗

  Over 49.5
• SF 26–23

  Oct 2, 2025 · W5 · @ LA
  +8.5 ✓

  Over 43.5
• SF 6–12

  Dec 12, 2024 · W15 · @ SF
  −3 ✗

  Under 48.5
• SF 24–27

  Sep 22, 2024 · W3 · @ LA
  −6 ✗

  Over 44.5
• SF 20–21

  Jan 7, 2024 · W18 · @ SF
  −5.5 ✗

  Over 40
• SF 30–23

  Sep 17, 2023 · W2 · @ LA
  −7.5 ✗

  Over 45
• SF 31–14

  Oct 30, 2022 · W8 · @ LA
  −1 ✓

  Over 42
• SF 24–9

  Oct 3, 2022 · W4 · @ SF
  −1 ✓

  Under 42
• SF 17–20

  Jan 30, 2022 · CONF · @ LA
  +3.5 ✓

  Under 45.5
• SF 27–24

  Jan 9, 2022 · W18 · @ LA
  +3 ✓

  Over 46.5
• SF 31–10

  Nov 15, 2021 · W10 · @ SF
  +3.5 ✓

  Under 50
• SF 23–20

  Nov 29, 2020 · W12 · @ LA
  +5 ✓

  Under 44.5
• SF 24–16

  Oct 18, 2020 · W6 · @ SF
  +2 ✓

  Under 51
• SF 34–31

  Dec 21, 2019 · W16 · @ SF
  −7 ✗

  Over 45.5
• SF 20–7

  Oct 13, 2019 · W6 · @ LA
  +3 ✓

  Under 49.5
• SF 32–48

  Dec 30, 2018 · W17 · @ LA
  +10.5 ✗

  Over 50.5
• SF 10–39

  Oct 21, 2018 · W7 · @ SF
  +8 ✗

  Under 52
• SF 34–13

  Dec 31, 2017 · W17 · @ LA
  −6.5 ✓

  Over 44.5
• SF 39–41

  Sep 21, 2017 · W3 · @ SF
  +3 ✓

  Over 40.5
• SF 22–21

  Dec 24, 2016 · W16 · @ LA
  +6 ✓

  Over 39.5